The Big Picture

Consuming orange juice significantly impacts the effectiveness of Adderall and Vyvanse - making them less effective but OJ has no effect on Ritalin and Concerta. It comes down to how each medication works once in your body.

In Depth

Vitamin C (found in orange juice) is particularly good at turning the urine acidic. Once urine is acidic, the kidneys filter out amphetamine-based medications, like Adderall and Vyvanse; they get trapped in the urine and cannot be reabsorbed, ending your dose prematurely.

Whereas Ritalin and Concerta (methylphenidate) can be filtered and reabsorbed by the kidneys many times, only finally being removed once the liver breaks them down—staying in the blood and crossing into the brain many times before the liver breaks them down.