Magnesium is the single most important mineral supplement for anyone managing their ADHD with Strattera. While it is widely known for relieving muscle cramps, its true value lies in its direct interaction with the brain's receptor systems.

Strattera (atomoxetine) alters norepinephrine reuptake and interacts specifically with the NMDA receptor. Pharmacological studies reveal that atomoxetine functions as an NMDA receptor blocker. Interestingly, magnesium ions and atomoxetine share a common binding site on these receptors.

Defending Against Tolerance

The NMDA receptor is heavily involved in learning, memory, and the development of drug tolerance. A chronic deficiency in magnesium allows excess calcium to flood these receptors, putting the brain in a state of hyperexcitability. Over time, this forces the brain to downregulate its response to the medication.

By taking magnesium glycinate daily, you ensure your NMDA receptors remain adequately blocked by magnesium ions, preserving the long-term effectiveness of the Strattera and preventing the common complaint of the medication "stopping working" after six months.

Easing Physical Side Effects

Because Strattera elevates circulating norepinephrine, your body operates in a mildly heightened state of alertness. This often manifests as poor sleep quality, subtle jaw clenching, and an inability to physically relax in the evenings.

Magnesium glycinate acts as the physical brake pedal. Glycinate is highly bioavailable and attached to glycine, an amino acid that lowers core body temperature and promotes deep recovery sleep.

If you take Strattera, you should be taking 200mg to 400mg of magnesium glycinate one to two hours before bed. This protocol clears out the physical tension from the day and protects your overarching neurological health for the years to come.